【学術論文】

• Do, T.L., Tachibana, K., Yamamoto, N., Ando, K., Isoda, T., Kihara, T., Interaction of SARS-CoV-2 Spike protein with ACE2 induces cortical actin modulation, including dephosphorylation of ERM proteins and reduction of cortical stiffness, Human Cell, 38, 3 (2025)
• Tachibana, K., Nakamura, Y., Do, T.L., Kihara, T., Kawada, H., Yamamoto, N., Ando, K., Mutations in the SARS-CoV-2 Spike proteins affected the ACE2-binding affinity during the development of Omicron pandemic variants, Biochem Biophys Res Commun, 719, 150120 (2024) 
• Phan, T.K.T., Do, T.L., Tachibana, K., Kihara, T., Alpha-mangostin dephosphorylates ERM to induce adhesion and decrease surface stiffness in KG-1 cells, Human Cell, 35, 189-198 (2022) 
• Kihara, T., Matsumoto, T., Nakahashi, Y., Tachibana, K., Mechanical stiffness softening and cell adhesion are coordinately regulated by ERM dephosphorylation in KG-1 cells, Human Cell, 34, 1709-1716 (2021)
• Phan, T.K.T., Shahbazzadeh, F., Kihara, T., Alpha-mangostin reduces mechanical stiffness of various cells, Human Cell, 33, 347-355 (2020)
• Tachibana, K., Ohnishi, H., Haghparast, S.M.A., Kihara, T., Miyake, J., Activation of PKC induces leukocyte adhesion by the dephosphorylation of ERM, Biochem Biophys Res Commun, 523 (1), 177-182 (2020)
• Kihara, T., Umezu, C., Sawada, K., Furutani, Y., Osteogenic cells form mineralized particles, a few μm in size, in a 3D collagen gel culture, PeerJ, 7, e7889 (2019)   
• Dung H. T. Nguyen, Ngoc B. Nguyen, Linh T. P. Nguyen, Ly T. Do, Tung T. Nguyen, Nam H. Nguyen, Sakurai Kazuo, Mochizuki Shinichi, Kihara Takanori, Thang D. Nguyen, Anh T. V. Nguyen & Huong T. T. Pham , An Agarose-Curdlan Nanogel that Carries Etanercept to Target and Neutralises TNF-α Produced by Dectin-1-Expressing Immune Cells, Journal of Electronic Materials, 48 (10), 6570-6582 (2019)
• Phan, T.K.T., Shahbazzadeh, F., Pham, T.T.H., Kihara, T., Alpha-mangostin inhibits the migration and invasion of A549 lung cancer cells, PeerJ, 6, e5027 (2018)
• Kihara, T., Sugimoto, Y., Shinohara, S., Takaoka, S., Miyake, J., Cysteine-rich protein 2 accelerates actin filament cluster formation, PLoS One, 12 (8), e0183085 (2017)
• Kihara, T., Kashitani, K., Miyake, J., In silico characterization of cell-cell interactions using a cellular automata model of cell culture, BMC Res Notes, 10 (1), 283 (2017)
• Haghparast, S.M.A., Kihara, T., Miyake, J., Distinct mechanical behavior of HEK293 cells in adherent and suspended states, PeerJ, 3, e1131 (2015)
• Han, S.W., Morita, K., Simona, P., Kihara, T., Miyake, J., Banu, M., Adachi, T., Probing Actin Filament and Binding Protein Interaction Using an Atomic Force Microscopy, J. Nanosci. Nanotechnol., 14 (8), 5654-5657 (2014)
• Kihara, T., Ito, J., Miyake, J., Measurement of biomolecular diffusion in extracellular matrix condensed by fibroblasts using fluorescence correlation spectroscopy, PLoS ONE, 8 (11), e82382 (2013)
• Yamaguchi, S., Komiya, S., Matsunuma, E., Yamahira, S., Kihara, T., Miyake, J., Nagamune, T., Transfer printing of transfected cell microarrays from poly(ethylene glycol)-oleyl surfaces onto biological hydrogels, Biotechnol Bioeng., 110 (12), 3269-3274 (2013)
• Haghparast, S.M.A., Kihara, T., Shimizu, Y., Yuba, S., Miyake, J., Actin-based biomechanical features of suspended normal and cancer cells, J. Biosci. Bioeng., 116 (3), 380-385 (2013)
• Shinohara, S., Kihara, T., Sakai, S., Matsusaki, M., Akashi, M., Taya, M., Miyake, J., Fabrication of in vitro three-dimensional multilayered blood vessel model using human endothelial and smooth muscle cells and high-strength PEG hydrogel, J. Biosci. Bioeng., 116 (2), 231-234 (2013)
• Kihara, T., Yoshida, T., Haghparast, S.M.A., Miyake, J., Elasticity mapping analysis of apical cell periphery actin structures of normal fibroblasts and cervical cancer cells, J. Analytical Sciences, Methods and Instrumentation, 3 (2), 124-129 (2013)
• Silberberg, Y.R., Mieda, S., Amemiya, Y., Sato, T., Kihara, T., Nakamura, N., Fukazawa, K., Ishihara, K., Miyake, J., Nakamura, C., Evaluation of the actin cytoskeleton state using an antibody-functionalized nanoneedle and an AFM, Biosensors and Bioelectronics, 40 (1), 3-9 (2013)
• Sakai, S., Inagaki, H., Liu, Y., Matsuyama, T., Kihara, T., Miyake, J., Kawakami, K., Taya, M., Rapidly serum-degradable hydrogel templating fabrication of spherical tissues and curved tubular structures, Biotechnology and Bioengineering, 109 (11), 2911-2919 (2012)
• Shimizu, Y., Haghparast, S.M.A., Kihara, T., Miyake, J., Cortical rigidity of round cells in mitotic phase and suspended state, Micron, 43 (12), 1246-12251 (2012)
• Shimizu, Y., Kihara, T., Haghparast, S.M.A., Yuba, S., Miyake, J., Simple display system of mechanical properties of cells and their dispersion, PLoS ONE, 7 (3), e34305 (2012)
• Mieda, S., Amemiya, Y., Kihara, T., Okada, T., Sato, T., Fukazawa, K., Ishihara, K., Nakamura, N., Miyake, J., Nakamura, C., Mechanical force-based probing of intracellular proteins from living cells using antibody-immobilized nanoneedles, Biosens Bioelectron, 31 (1), 323-329 (2012)
• Kihara, T., Shinohara, S., Fujikawa, R., Sugimoto, Y., Murata, M., Miyake, J., Regulation of cysteine-rich protein 2 localization by the development of actin fibers during smooth muscle cell differentiation, Biochemical and Biophysical Research Communications, 411 (1), 96-101 (2011)
• Kihara, T., Liu, X.Y., Nakamura, C., Park, K.M., Han, S.W., Qian, D.J., Kawasaki, K., Zorin, N.A., Yasuda, S., Hata, K., Wakayama, T., Miyake, J., Direct electron transfer to hydrogenase for catalytic hydrogen production using a single-walled carbon nanotube forest, International Journal of Hydrogen Energy, 36(13), 7253-7529 (2011)
• Kihara, T., Zhang, Y., Hu, Y., Mao, Q., Tang, Y., Miyake, J., Effect of composition, morphology and size of nanozeolite on its in vitro cytotoxicity, Journal of Bioscience and Bioengineering, 111(6), 725-730 (2011)
• Kihara, T., Haghparast, S.M.A., Shimizu, Y., Yuba, S., Miyake, J., Physical properties of mesenchymal stem cells are coordinated by the perinuclear actin cap, Biochemical and Biophysical Research Communications, 409(1), 1-6 (2011)
• Han, S.W., Mieda, S., Nakamura, C., Kihara, T., Nakamura, N., Miyake, J., Successive detection of insulin-like growth factor-II bound to receptors on a living cell surface using an AFM, Journal of Molecular Recognition, 24(1), 17-22 (2011)
• Kihara, T., Yoshida, N., Kitagawa, T., Nakamura, C., Nakamura, N., Miyake, J., Development of a novel method to detect intrinsic mRNA in a living cell by using a molecular beacon-immobilized nanoneedle, Biosensors and Bioelectronics, 26(4), 1449-1454 (2010)
• Kagiwada, H., Nakamura, C., Kihara, T., Kamiishi, H., Kawano, K., Nakamura, N., Miyake, J., The mechanical properties of a cell, as determined by its actin cytoskeleton, are important for nanoneedle insertion into a living cell, Cytoskeleton, 67(8), 496-503 (2010)
• Kihara, T., Nakamura, C., Suzuki, M., Han, S.W., Fukazawa, K., Ishihara, K., Miyake, J., Development of a method to evaluate caspase-3 activity in a single cell using a nanoneedle and a fluorescent probe, Biosensors and Bioelectronics, 25 (1), 22-27 (2009)
• Sugitate, T., Kihara, T., Liu, X.Y., Miyake, J., Mechanical role of the nucleus in a cell in terms of elastic modulus, Current Applied Physics, 9 (4), e291-e293 (2009)
• Kihara, T., Kano, F., Murata, M., Modulation of SRF-dependent gene expression by association of SPT16 with MKL1, Experimental Cell Research, 314 (3), 629-637 (2008)
• Kihara, T., Imamura, Y., Takemura, Y., Mizuno, K., Adachi, E., Hayashi, T., Intercellular accumulation of type V collagen fibrils in accordance with cell aggregation, Journal of Biochemistry, 144 (5), 625-633 (2008)
• Kihara, T., Yoshida, N., Mieda, S., Fukuzawa, K., Nakamura, C., Ishihara, K., Miyake, J., Nanoneedle surface modification with 2-methacryloyloxyethyl phosphorylcholine polymer to reduce nonspecific protein adsorption in a living cell, NanoBiotechnology, 3 (2), 127-134 (2007)
• Kihara, T., Hirose, M., Oshima, A., Ohgushi, H., Exogenous type I collagen facilitates osteogenic differentiation and acts as a substrate for mineralization of rat marrow mesenchymal stem cells in vitro, Biochemical Biophysical Research Communications, 341 (4), 1029-1035 (2006)
• Kihara, T., Oshima, A., Hirose, M., Ohgushi, H., Three-dimensional visualization analysis of in vitro cultured bone fabricated by rat marrow mesenchymal stem cells, Biochemical Biophysical Research Communications, 316 (3), 943-948 (2004)
• Kihara, T., Takemura, Y., Imamura, Y., Mizuno, K., Hayashi, T., Reconstituted type V collagen fibrils as cementing materials in the formation of cell clumps in culture, Cell and Tissue Research, 318 (2), 343-352 (2004)
• Uchimura, E., Machida, H., Kotobuki, N., Kihara, T., Kitamura, S., Ikeuchi, M., Hirose, M., Miyake, J., Ohgushi, H., In situ visualization and quantification of mineralization of cultured osteogenetic cells, Calcified Tissue International, 73 (6), 575-583 (2003)

【総説・解説】

• 木原隆典, 立花宏一, 「機械的物性から読み取る白血球接着」, Medical Science Digest, 48 (11), 46-47 (2022)
• Kihara, T., Three-dimensional mineralized tissue formation of cultured bone marrow stromal cells, Hyper Bio Assembler for 3D Cellular Systems, Arai, T., Arai, F., Yamato, M. (ed.), Springer, pp.317-326 (2015)
• Shinohara, S., Shinohara, S., Kihara, T., Miyake, J., Regulation of differentiated phenotypes of vascular smooth muscle cells, Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues - From Molecules to Humans, Sugi, H. (ed), InTech, pp331-344 (2012)
• 木原隆典, 中村 史, 三宅 淳, 「ナノニードルによる細胞内分子評価と生体適合性高分子の利用」, ファインケミカル, 40 (10), 33-40 (2011) 
• 中村 史, 雨宮陽介, 木原隆典, 鍵和田晴美, 中村徳幸, 三宅 淳, 「AFMを利用したナノニードルによる単一細胞操作と計測」, Electrochemistry, 78 (10), 841-845 (2010) 
• 中村 史, 雨宮陽介, 木原隆典, 三宅淳, 「FRET分子プローブ修飾ナノニードルを用いた細胞内解析技術の開発」, 表面科学, 31 (9), 459-465 (2010)　
• 木原隆典, 中村　史, 三宅　淳, 「遺伝子導入技術」, Medical Bio, Sep, 46-49 (2009)
• 中村　史, 韓　成雄, 木原隆典, 三宅　淳, 「ナノ針を用いた細胞への遺伝子導入操作」, 化学工学, 72 (9), 476-479 (2008)
• 三宅　淳, 木原隆典, 中村史, 「ナノテクノロジーを用いた細胞操作」, 分子細胞治療, 7 (1), 18-25 (2008)
• Hayashi, T., Hirose, M., Yamano, H., Takeda, Y., Kosugi, H., Kihara, T., Imamura, Y., Mizuno, K., Nakazato, K., Yoshikawa, K., Kajimura, D., Takahashi, S., Adachi, E., Regulation of phenotypes of human aorta endothelial cells and smooth muscle cells in culture by type IV collagen aggregates, Extracellular Matrix and the Liver. Okazaki, I., Ninomiya, Y., Friedman, S.L., Tanikawa, K. (eds), Academic Press, pp.39-54 (2003)
• 水野一乘, 木原隆典, 今村保忠, 安達栄治郎, 林 利彦, 「線維性コラーゲンとその会合体の生物学的機能」, 電子顕微鏡, 35 (3), 245-247 (2000)